Which of the following is true about corticotropin (ACTH)? 1) ACTH is not a commonly prescribed medication because of severe adverse reactions. 2) ACTH can be given orally, intravenously or intramuscularly. 3) Clients with diabetes taking ACTH may experience a need for an increase in their insulin dosage. 4) ACTH is the treatment of choice for hyperpituitarism.