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Organisms can be classified into one of three domains based on differences in the sequences of nucleotides in the cell's ribosomal RNAs (rRNA), the cell's membrane lipid structure, and its sensitivity to antibiotics. 3. The three domains are the Archaea, the Bacteria, and the Eukarya.
The three-domain system is a biological classification introduced by Carl Woese et al. in 1977 that divides cellular life forms into archaea, bacteria, and eukaryote domains.

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